Low Dose THC May Restore Cognitive Function in Aging Patients

A collaborative study between Universities in Israel and Germany found the Endocannabinoid System (ECS) to have a homeostatic effect on body mechanisms that determine aging.  This modulation of the underlying physical properties that regulate and determine aging has long thought to have been connected; however previously, no direct links between the ECS and aging symptoms have been demonstrated in controlled environments.

This study showed that low doses of delta 9 – tetrahydrocannabinol (THC) reversed age related cognitive performance declines in mice aged 12 to 18 months through the restoration of CB1 receptors.  Behavioral effects were coupled with physical effects through measured increases in marker proteins and increased hippocampal spine density.

Physical comparisons between the 12 month old THC treated mice were found to be comparable to that of 2 month old, untreated mice.  This study shows, cannabis treatment and the restoration of CB1 receptors, of which cannabis is uniquely shaped to influence within our ECS, could be a viable alternative for treating age related cognitive issues.

For more information, the full study can be found here.

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